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Structural characterisation of inhibitory and non-inhibitory MMP-9–TIMP-1 complexes and implications for regulatory mechanisms of MMP-9

MMP-9 plays a number of important physiological functions but is also responsible for many pathological processes, including cancer invasion, metastasis, and angiogenesis. It is, therefore, crucial to understand its enzymatic activity, including activation and inhibition mechanisms. This enzyme may...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Charzewski, Łukasz, Krzyśko, Krystiana A., Lesyng, Bogdan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238946/
https://ncbi.nlm.nih.gov/pubmed/34183752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92881-x
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