Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α

BACKGROUND: Statins such as simvastatin are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase used in the prevention of cardiovascular disease. In addition to their cholesterol-lowering activities, statins exert pleiotropic anti-inflammatory effects, which might contribute to t...

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Autori principali: Esposito, Emanuela, Rinaldi, Barbara, Mazzon, Emanuela, Donniacuo, Maria, Impellizzeri, Daniela, Paterniti , Irene, Capuano, Annalisa, Bramanti, Placido, Cuzzocrea, Salvatore
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372420/
https://ncbi.nlm.nih.gov/pubmed/22537532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-81
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