MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma

BACKGROUND: Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of spinal cord injury (SCI). The aim of this study was to investigate the neuroprotective effect of dizocilpine maleate, MK801 (2 mg/Kg, 30 min and 6 hours after injury) in a mice model of SCI. Th...

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Main Authors: Esposito, Emanuela, Paterniti, Irene, Mazzon, Emanuela, Genovese, Tiziana, Galuppo, Maria, Meli, Rosaria, Bramanti, Placido, Cuzzocrea, Salvatore
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094200/
https://ncbi.nlm.nih.gov/pubmed/21492450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-12-31
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