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Decreased translation of p21(waf1) mRNA causes attenuated p53 signaling in some p53 wild-type tumors
DNA damage induces cell cycle arrest through both Chk1 and the p53 tumor suppressor protein, the latter arresting cells through induction of p21(waf1) protein. Arrest permits cells to repair the damage and recover. The frequent loss of p53 in tumor cells makes them more dependent on Chk1 for arrest...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Landes Bioscience
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372393/ https://ncbi.nlm.nih.gov/pubmed/22510560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20208 |
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