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Decreased translation of p21(waf1) mRNA causes attenuated p53 signaling in some p53 wild-type tumors
DNA damage induces cell cycle arrest through both Chk1 and the p53 tumor suppressor protein, the latter arresting cells through induction of p21(waf1) protein. Arrest permits cells to repair the damage and recover. The frequent loss of p53 in tumor cells makes them more dependent on Chk1 for arrest...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372393/ https://ncbi.nlm.nih.gov/pubmed/22510560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20208 |
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