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Differential regulation of p21(waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications
DNA damage induces the canonical p53 pathway including elevation of p21(waf1) resulting in arrest of cell cycle progression. This can protect cells from subsequent Chk1 inhibition. Some p53 wild-type cancer cells such as HCT116 and U2OS exhibit attenuated p21(waf1) induction upon DNA damage due to t...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Landes Bioscience
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461812/ https://ncbi.nlm.nih.gov/pubmed/22825333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.21047 |
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