Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer

Colorectal cancer (CRC) remains a major cause of cancer mortality worldwide. Murine models have yielded critical insights into CRC pathogenesis, but they often fail to recapitulate advanced-disease phenotypes, notably metastasis and chromosomal instability (CIN). New models are thus needed to unders...

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Detalhes bibliográficos
Main Authors: Grim, Jonathan E., Knoblaugh, Sue E., Guthrie, Katherine A., Hagar, Amanda, Swanger, Jherek, Hespelt, Jessica, Delrow, Jeffrey J., Small, Tom, Grady, William M., Nakayama, Keiichi I., Clurman, Bruce E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372235/
https://ncbi.nlm.nih.gov/pubmed/22473991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00305-12
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