Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors...

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Detalhes bibliográficos
Main Authors: Hoeffel, Guillaume, Wang, Yilin, Greter, Melanie, See, Peter, Teo, Pearline, Malleret, Benoit, Leboeuf, Marylène, Low, Donovan, Oller, Guillaume, Almeida, Francisca, Choy, Sharon H.Y., Grisotto, Marcos, Renia, Laurent, Conway, Simon J., Stanley, E. Richard, Chan, Jerry K.Y., Ng, Lai Guan, Samokhvalov, Igor M., Merad, Miriam, Ginhoux, Florent
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371735/
https://ncbi.nlm.nih.gov/pubmed/22565823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120340
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