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SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage
Here we demonstrate that RNF4, a highly conserved small ubiquitin-like modifier (SUMO)-targeted ubiquitin E3 ligase, plays a critical role in the response of mammalian cells to DNA damage. Human cells in which RNF4 expression was ablated by siRNA or chicken DT40 cells with a homozygous deletion of t...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371408/ https://ncbi.nlm.nih.gov/pubmed/22661230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.189274.112 |
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