Multiple Genetic Loci Influence Serum Urate and Their Relationship with Gout and Cardiovascular Disease Risk Factors

BACKGROUND: Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed genome-wide association to search for genetic susceptibility loci for serum urate and gout, and investigated the causal nature of the associations of serum urate with gout and s...

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Detalhes bibliográficos
Main Authors: Yang, Qiong, Köttgen, Anna, Dehghan, Abbas, Smith, Albert V., Glazer, Nicole L., Chen, Huei, Chasman, Daniel I., Aspelund, Thor, Eiriksdottir, Gudny, Harris, Tamara B., Launer, Lenore, Nalls, Michael, Hernandez, Dena, Arking, Dan E, Boerwinkle, Eric, Grove, Megan L., Li, Man, Kao, WH Linda, Chonchol, Michel, Haritunians, Talin, Li, Guo, Lumley, Thomas, Psaty, Bruce M., Shlipak, Michael, Hwang, Shih-Jen, Larson, Martin G., O’Donnell, Christopher J., Upadhyay, Ashish, van Duijn, Cornelia M., Hofman, Albert, Rivadeneira, Fernando, Stricker, Bruno, Uitterlinden, Andre G., Paré, Guillaume, Parker, Alex N., Ridker, Paul M, Siscovick, David S., Gudnason, Vilmundur, Witteman, Jacqueline C., Fox, Caroline S., Coresh, Josef
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371395/
https://ncbi.nlm.nih.gov/pubmed/20884846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.109.934455
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