Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation Measurements

Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues are ensembles of cells that may each have their own epigenetic profile, and therefore inter-individual cellular heterogeneity may compromise these studies. Here, we explore the potential for such confounding on DN...

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Detalhes bibliográficos
Main Authors: Adalsteinsson, Bjorn T., Gudnason, Haukur, Aspelund, Thor, Harris, Tamara B., Launer, Lenore J., Eiriksdottir, Gudny, Smith, Albert V., Gudnason, Vilmundur
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465258/
https://ncbi.nlm.nih.gov/pubmed/23071618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046705
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