Multiple Genetic Loci Influence Serum Urate and Their Relationship with Gout and Cardiovascular Disease Risk Factors

BACKGROUND: Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed genome-wide association to search for genetic susceptibility loci for serum urate and gout, and investigated the causal nature of the associations of serum urate with gout and s...

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Hlavní autoři: Yang, Qiong, Köttgen, Anna, Dehghan, Abbas, Smith, Albert V., Glazer, Nicole L., Chen, Huei, Chasman, Daniel I., Aspelund, Thor, Eiriksdottir, Gudny, Harris, Tamara B., Launer, Lenore, Nalls, Michael, Hernandez, Dena, Arking, Dan E, Boerwinkle, Eric, Grove, Megan L., Li, Man, Kao, WH Linda, Chonchol, Michel, Haritunians, Talin, Li, Guo, Lumley, Thomas, Psaty, Bruce M., Shlipak, Michael, Hwang, Shih-Jen, Larson, Martin G., O’Donnell, Christopher J., Upadhyay, Ashish, van Duijn, Cornelia M., Hofman, Albert, Rivadeneira, Fernando, Stricker, Bruno, Uitterlinden, Andre G., Paré, Guillaume, Parker, Alex N., Ridker, Paul M, Siscovick, David S., Gudnason, Vilmundur, Witteman, Jacqueline C., Fox, Caroline S., Coresh, Josef
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371395/
https://ncbi.nlm.nih.gov/pubmed/20884846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.109.934455
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