The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification

BACKGROUND: In nematodes, plants and fungi, RNAi is remarkably potent and persistent due to the amplification of initial silencing signals by RNA-dependent RNA polymerases (RdRPs). In Caenorhabditis elegans (C. elegans), the interaction between the RNA-induced silencing complex (RISC) loaded with pr...

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Main Authors: Zhang, Chi, Montgomery, Taiowa A., Fischer, Sylvia E. J., Garcia, Susana M. D. A., Riedel, Christian G., Fahlgren, Noah, Sullivan, Christopher M., Carrington, James C., Ruvkun, Gary
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371361/
https://ncbi.nlm.nih.gov/pubmed/22542102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.04.011
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