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piRNAs and piRNA-dependent siRNAs protect conserved and essential C. elegans genes from misrouting into the RNAi pathway
piRNAs silence foreign genes, such as transposons, to preserve genome integrity, but also target endogenous mRNAs by mechanisms that are poorly understood. C. elegans piRNAs interact with both transposon and non-transposon mRNAs to initiate sustained silencing via the RNAi pathway. To assess the dys...
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| 出版年: | Dev Cell |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4550515/ https://ncbi.nlm.nih.gov/pubmed/26279487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.07.009 |
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