piRNAs and piRNA-dependent siRNAs protect conserved and essential C. elegans genes from misrouting into the RNAi pathway

piRNAs silence foreign genes, such as transposons, to preserve genome integrity, but also target endogenous mRNAs by mechanisms that are poorly understood. C. elegans piRNAs interact with both transposon and non-transposon mRNAs to initiate sustained silencing via the RNAi pathway. To assess the dys...

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Detaylı Bibliyografya
Yayımlandı:Dev Cell
Asıl Yazarlar: Phillips, Carolyn M., Brown, Kristen C., Montgomery, Brooke E., Ruvkun, Gary, Montgomery, Taiowa A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550515/
https://ncbi.nlm.nih.gov/pubmed/26279487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.07.009
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