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piRNAs and piRNA-dependent siRNAs protect conserved and essential C. elegans genes from misrouting into the RNAi pathway

piRNAs silence foreign genes, such as transposons, to preserve genome integrity, but also target endogenous mRNAs by mechanisms that are poorly understood. C. elegans piRNAs interact with both transposon and non-transposon mRNAs to initiate sustained silencing via the RNAi pathway. To assess the dys...

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Vydáno v:Dev Cell
Hlavní autoři: Phillips, Carolyn M., Brown, Kristen C., Montgomery, Brooke E., Ruvkun, Gary, Montgomery, Taiowa A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550515/
https://ncbi.nlm.nih.gov/pubmed/26279487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.07.009
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