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piRNAs and piRNA-dependent siRNAs protect conserved and essential C. elegans genes from misrouting into the RNAi pathway

piRNAs silence foreign genes, such as transposons, to preserve genome integrity, but also target endogenous mRNAs by mechanisms that are poorly understood. C. elegans piRNAs interact with both transposon and non-transposon mRNAs to initiate sustained silencing via the RNAi pathway. To assess the dys...

詳細記述

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書誌詳細
出版年:Dev Cell
主要な著者: Phillips, Carolyn M., Brown, Kristen C., Montgomery, Brooke E., Ruvkun, Gary, Montgomery, Taiowa A.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550515/
https://ncbi.nlm.nih.gov/pubmed/26279487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.07.009
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