A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent RNA polymerase. However, the steps b...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Manage, Kevin I, Rogers, Alicia K, Wallis, Dylan C, Uebel, Celja J, Anderson, Dorian C, Nguyen, Dieu An H, Arca, Katerina, Brown, Kristen C, Cordeiro Rodrigues, Ricardo J, de Albuquerque, Bruno FM, Ketting, René F, Montgomery, Taiowa A, Phillips, Carolyn Marie
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255803/
https://ncbi.nlm.nih.gov/pubmed/32338603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56731
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