K(+) Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking these events are unknown. We identify two recurrent somatic mutations in and near the selectivit...

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Detalhes bibliográficos
Main Authors: Choi, Murim, Scholl, Ute I., Yue, Peng, Björklund, Peyman, Zhao, Bixiao, Nelson-Williams, Carol, Ji, Weizhen, Cho, Yoonsang, Patel, Aniruddh, Men, Clara J., Lolis, Elias, Wisgerhof, Max V., Geller, David S., Mane, Shrikant, Hellman, Per, Westin, Gunnar, Åkerström, Göran, Wang, Wenhui, Carling, Tobias, Lifton, Richard P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371087/
https://ncbi.nlm.nih.gov/pubmed/21311022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1198785
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