Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas

Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia. Exome and targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in the DNA-binding zinc finger of the transcription factor Yin Yang 1 (YY1). Chromatin immuno...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cromer, M. Kyle, Choi, Murim, Nelson-Williams, Carol, Fonseca, Annabelle L., Kunstman, John W., Korah, Reju M., Overton, John D., Mane, Shrikant, Kenney, Barton, Malchoff, Carl D., Stalberg, Peter, Akerström, Göran, Westin, Gunnar, Hellman, Per, Carling, Tobias, Björklund, Peyman, Lifton, Richard P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386328/
https://ncbi.nlm.nih.gov/pubmed/25787250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503696112
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