Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas

Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia. Exome and targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in the DNA-binding zinc finger of the transcription factor Yin Yang 1 (YY1). Chromatin immuno...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Cromer, M. Kyle, Choi, Murim, Nelson-Williams, Carol, Fonseca, Annabelle L., Kunstman, John W., Korah, Reju M., Overton, John D., Mane, Shrikant, Kenney, Barton, Malchoff, Carl D., Stalberg, Peter, Akerström, Göran, Westin, Gunnar, Hellman, Per, Carling, Tobias, Björklund, Peyman, Lifton, Richard P.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2015
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386328/
https://ncbi.nlm.nih.gov/pubmed/25787250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503696112
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