Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance

The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaq...

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Autori principali: Diacon, A. H., Donald, P. R., Pym, A., Grobusch, M., Patientia, R. F., Mahanyele, R., Bantubani, N., Narasimooloo, R., De Marez, T., van Heeswijk, R., Lounis, N., Meyvisch, P., Andries, K., McNeeley, D. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Clinical Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370813/
https://ncbi.nlm.nih.gov/pubmed/22391540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06126-11
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