The Combination of Doripenem and Colistin Is Bactericidal and Synergistic against Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae

We tested two-drug combinations of doripenem, colistin, gentamicin, and doxycycline against 12 carbapenemase-producing Klebsiella pneumoniae (KPC) isolates by time-kill. The combination of doripenem and colistin reduced the starting inocula by 2 logs for each isolate (range, 2.02 to 6.01 log(10)) an...

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Bibliografiske detaljer
Main Authors: Jernigan, Meredith G., Press, Ellen G., Nguyen, M. Hong, Clancy, Cornelius J., Shields, Ryan K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370798/
https://ncbi.nlm.nih.gov/pubmed/22430958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06364-11
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