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Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer

Neuroprotectin D1 / protectin D1, a potent anti-inflammatory, proresolving, and neuroprotective lipid mediator derived biosynthetically from docosahexaenoic acid, was prepared in enantiomerically pure form via total organic synthesis. The synthetic strategy is highly stereocontrolled and convergent,...

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Bibliografski detalji
Glavni autori: Petasis, Nicos A., Yang, Rong, Winkler, Jeremy W., Zhu, Min, Uddin, Jasim, Bazan, Nicolas G., Serhan, Charles N.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370686/
https://ncbi.nlm.nih.gov/pubmed/22690022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2012.01.032
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