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Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis

Alnumycin A is an aromatic polyketide with a strong resemblance to related benzoisochromanequinone (BIQ) antibiotics, such as the model antibiotic actinorhodin. One intriguing difference between these metabolites is that the positions of the benzene and quinone rings are reversed in alnumycin A in c...

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Detalhes bibliográficos
Main Authors: Grocholski, Thadée, Oja, Terhi, Humphrey, Laurence, Mäntsälä, Pekka, Niemi, Jarmo, Metsä-Ketelä, Mikko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370643/
https://ncbi.nlm.nih.gov/pubmed/22467789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00228-12
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