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Precise Manipulation of the Clostridium difficile Chromosome Reveals a Lack of Association between the tcdC Genotype and Toxin Production

Clostridium difficile causes a potentially fatal diarrheal disease through the production of its principal virulence factors, toxin A and toxin B. The tcdC gene is thought to encode a negative regulator of toxin production. Therefore, increased toxin production, and hence increased virulence, is oft...

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主要な著者: Cartman, Stephen T., Kelly, Michelle L., Heeg, Daniela, Heap, John T., Minton, Nigel P.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370502/
https://ncbi.nlm.nih.gov/pubmed/22522680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00249-12
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