Precise Manipulation of the Clostridium difficile Chromosome Reveals a Lack of Association between the tcdC Genotype and Toxin Production

Clostridium difficile causes a potentially fatal diarrheal disease through the production of its principal virulence factors, toxin A and toxin B. The tcdC gene is thought to encode a negative regulator of toxin production. Therefore, increased toxin production, and hence increased virulence, is oft...

Full description

Saved in:
Bibliographic Details
Main Authors: Cartman, Stephen T., Kelly, Michelle L., Heeg, Daniela, Heap, John T., Minton, Nigel P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370502/
https://ncbi.nlm.nih.gov/pubmed/22522680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00249-12
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items