Heavy Chains of Inter Alpha Inhibitor (IαI) Inhibit the Human Complement System at Early Stages of the Cascade

Inter alpha inhibitor (IαI) is an abundant serum protein consisting of three polypeptides: two heavy chains (HC1 and HC2) and bikunin, a broad-specificity Kunitz-type proteinase inhibitor. The complex is covalently held together by chondroitin sulfate but during inflammation IαI may interact with TN...

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Main Authors: Okroj, Marcin, Holmquist, Emelie, Sjölander, Jonatan, Corrales, Leticia, Saxne, Tore, Wisniewski, Hans-Georg, Blom, Anna M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370193/
https://ncbi.nlm.nih.gov/pubmed/22528482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324913
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