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Heavy Chains of Inter Alpha Inhibitor (IαI) Inhibit the Human Complement System at Early Stages of the Cascade
Inter alpha inhibitor (IαI) is an abundant serum protein consisting of three polypeptides: two heavy chains (HC1 and HC2) and bikunin, a broad-specificity Kunitz-type proteinase inhibitor. The complex is covalently held together by chondroitin sulfate but during inflammation IαI may interact with TN...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3370193/ https://ncbi.nlm.nih.gov/pubmed/22528482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324913 |
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