Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

The blood vessels of cancerous tumours are leaky(1–3) and poorly organized(4–7). This can increase the interstitial fluid pressure (IFP) inside tumours and reduce blood supply to them, which impairs drug delivery(8–9). Anti-angiogenic therapies – which “normalize” the abnormal blood vessels in tumou...

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Hlavní autoři: Chauhan, Vikash P., Stylianopoulos, Triantafyllos, Martin, John D., Popović, Zoran, Chen, Ou, Kamoun, Walid S., Bawendi, Moungi G., Fukumura, Dai, Jain, Rakesh K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370066/
https://ncbi.nlm.nih.gov/pubmed/22484912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nnano.2012.45
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