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A Coevolutionary Residue Network at the Site of a Functionally Important Conformational Change in a Phosphohexomutase Enzyme Family

Coevolution analyses identify residues that co-vary with each other during evolution, revealing sequence relationships unobservable from traditional multiple sequence alignments. Here we describe a coevolutionary analysis of phosphomannomutase/phosphoglucomutase (PMM/PGM), a widespread and diverse e...

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Autors principals: Lee, Yingying, Mick, Jacob, Furdui, Cristina, Beamer, Lesa J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369874/
https://ncbi.nlm.nih.gov/pubmed/22685552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038114
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