Promotion of Enzyme Flexibility by Dephosphorylation and Coupling to the Catalytic Mechanism of a Phosphohexomutase

The enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from Pseudomonas aeruginosa catalyzes an intramolecular phosphoryl transfer across its phosphosugar substrates, which are precursors in the synthesis of exoproducts involved in bacterial virulence. Previous structural studies of PMM/PGM have...

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Bibliographic Details
Main Authors: Lee, Yingying, Villar, Maria T., Artigues, Antonio, Beamer, Lesa J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931030/
https://ncbi.nlm.nih.gov/pubmed/24403075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532226
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