DNA fragments binding CTCF in vitro and in vivo are capable of blocking enhancer activity

BACKGROUND: Earlier we identified ten 100-300-bp long CTCF-binding DNA fragments selected earlier from a 1-Mb human chromosome 19 region. Here the positive-negative selection technique was used to check the ability of CTCF-binding human genomic fragments to block enhancer-promoter interaction when i...

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Bibliographic Details
Main Authors:	Didych, Dmitry A, Kotova, Elena S, Akopov, Segey B, Nikolaev, Lev G, Sverdlov, Eugene D
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2012
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3369819/ https://ncbi.nlm.nih.gov/pubmed/22480385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-5-178
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DNA fragments binding CTCF in vitro and in vivo are capable of blocking enhancer activity

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