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Y95 and E444 Interaction Required for High-Affinity S-Citalopram Binding in the Human Serotonin Transporter

[Image: see text] The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) is responsible for the reuptake of 5-HT following synaptic release, as well as for import of the biogenic amine into several non-5-HT synthesizing cells including platelets. The antidepressant citalopram blocks SER...

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Autores principales: Combs, Steven, Kaufmann, Kristian, Field, Julie R., Blakely, Randy D., Meiler, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2010
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369724/
https://ncbi.nlm.nih.gov/pubmed/22778858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100066p
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