A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport

Na(+)- and Cl(−)-dependent uptake of neurotransmitters via transporters of the SLC6 family, including the human serotonin transporter (SLC6A4), is critical for efficient synaptic transmission. Although residues in the human serotonin transporter involved in direct Cl(−) coordination of human seroton...

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Bibliografske podrobnosti
Main Authors: Henry, L. Keith, Iwamoto, Hideki, Field, Julie R., Kaufmann, Kristian, Dawson, Eric S., Jacobs, Miriam T., Adams, Chelsea, Felts, Bruce, Zdravkovic, Igor, Armstrong, Vanessa, Combs, Steven, Solis, Ernesto, Rudnick, Gary, Noskov, Sergei Y., DeFelice, Louis J., Meiler, Jens, Blakely, Randy D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162443/
https://ncbi.nlm.nih.gov/pubmed/21730057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250308
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