A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport

Na(+)- and Cl(−)-dependent uptake of neurotransmitters via transporters of the SLC6 family, including the human serotonin transporter (SLC6A4), is critical for efficient synaptic transmission. Although residues in the human serotonin transporter involved in direct Cl(−) coordination of human seroton...

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Detalhes bibliográficos
Main Authors: Henry, L. Keith, Iwamoto, Hideki, Field, Julie R., Kaufmann, Kristian, Dawson, Eric S., Jacobs, Miriam T., Adams, Chelsea, Felts, Bruce, Zdravkovic, Igor, Armstrong, Vanessa, Combs, Steven, Solis, Ernesto, Rudnick, Gary, Noskov, Sergei Y., DeFelice, Louis J., Meiler, Jens, Blakely, Randy D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162443/
https://ncbi.nlm.nih.gov/pubmed/21730057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250308
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