“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

[Image: see text] The synthesis of a water/plasma soluble, noncytotoxic, “clicked” sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-β and tau peptide aggregation is presented. Curcumin inhibits amyloid-β and tau peptide aggregation at micromolar concentrations; the sugar...

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Detalhes bibliográficos
Main Authors: Dolai, Sukanta, Shi, Wei, Corbo, Christopher, Sun, Chong, Averick, Saadyah, Obeysekera, Dinali, Farid, Mina, Alonso, Alejandra, Banerjee, Probal, Raja, Krishnaswami
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369720/
https://ncbi.nlm.nih.gov/pubmed/22860163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200088r
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