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Extensive phosphorothioate substitution yields highly active and nuclease-resistant hairpin ribozymes.

The catalytic function of the hairpin ribozyme has been investigated by modification-interference analysis of both ribozyme and substrate, using ribonucleoside phosphorothioates. Thiophosphate substitutions in two ribozyme domains were examined by using a novel and highly efficient two-piece ribozym...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Chowrira, B M, Burke, J M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 1992
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC336929/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1377380/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.11.2835
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