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Extensive phosphorothioate substitution yields highly active and nuclease-resistant hairpin ribozymes.

The catalytic function of the hairpin ribozyme has been investigated by modification-interference analysis of both ribozyme and substrate, using ribonucleoside phosphorothioates. Thiophosphate substitutions in two ribozyme domains were examined by using a novel and highly efficient two-piece ribozym...

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Bibliografiska uppgifter
Huvudupphovsmän: Chowrira, B M, Burke, J M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC336929/
https://ncbi.nlm.nih.gov/pubmed/1377380
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