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Improving Pedigree-based Linkage Analysis by Estimating Coancestry Among Families

We present a method for improving the power of linkage analysis by detecting chromosome segments shared identical by descent (IBD) by individuals not known to be related. Existing Markov chain Monte Carlo methods sample descent patterns on pedigrees conditional on observed marker data. These pattern...

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Hlavní autoři: Glazner, Chris, Thompson, Elizabeth Alison
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368982/
https://ncbi.nlm.nih.gov/pubmed/22499699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2202/1544-6115.1718
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