EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth

Enforced EGFR activation upon gene amplification and/or mutation is a common hallmark of malignant glioma. Small molecule EGFR tyrosine kinase inhibitors, such as erlotinib (Tarceva), have shown some activity in a subset of glioma patients in recent trials, although the reported data on the cellular...

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Bibliographic Details
Main Authors: Ramis, Guillem, Thomàs-Moyà, Elena, Fernández de Mattos, Silvia, Rodríguez, José, Villalonga, Priam
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368887/
https://ncbi.nlm.nih.gov/pubmed/22701710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038770
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