Jacaranone Induces Apoptosis in Melanoma Cells via ROS-Mediated Downregulation of Akt and p38 MAPK Activation and Displays Antitumor Activity In Vivo

BACKGROUND: Malignant melanoma is a deadly type of metastatic skin cancer with increased incidence over the past 30 years. Despite the advanced knowledge on the biology, immunobiology and molecular genetics of melanoma, the alternatives of treatment are limited with poor prognosis. On clinical trial...

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Bibliografski detalji
Glavni autori: Massaoka, Mariana H., Matsuo, Alisson L., Figueiredo, Carlos R., Farias, Camyla F., Girola, Natália, Arruda, Denise C., Scutti, Jorge A. B., Romoff, Paulete, Favero, Oriana A., Ferreira, Marcelo J. P., Lago, João H. G., Travassos, Luiz R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368838/
https://ncbi.nlm.nih.gov/pubmed/22701695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038698
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