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A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems()

The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine–arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Massaoka, Mariana H., Matsuo, Alisson L., Figueiredo, Carlos R., Girola, Natalia, Faria, Camyla F., Azevedo, Ricardo A., Travassos, Luiz R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier 2014
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907745/
https://ncbi.nlm.nih.gov/pubmed/24490140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.01.007
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