Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer

PURPOSE: A phase I clinical trial and molecular correlative studies were performed to evaluate preclinical evidence for combinatorial activity of proteasome inhibitor bortezomib, epidermal growth factor receptor (EGFR) inhibitor cetuximab, and radiation therapy. EXPERIMENTAL DESIGN: Patients with ra...

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Hoofdauteurs: Argiris, Athanassios, Duffy, Austin G., Kummar, Shivaani, Simone, Nicole L., Arai, Yoshio, Kim, Seungwon W., Rudy, Susan. F., Kannabiran, Vishnu. R., Yang, Xinping, Jang, Minyoung, Chen, Zhong, Suksta, Nanette, Cooley-Zgela, Theresa, Ramanand, Susmita G., Ahsan, Aarif, Nyati, Mukesh. K., Wright, John J., Van Waes, Carter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368806/
https://ncbi.nlm.nih.gov/pubmed/21750205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0861
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