Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer

PURPOSE: A phase I clinical trial and molecular correlative studies were performed to evaluate preclinical evidence for combinatorial activity of proteasome inhibitor bortezomib, epidermal growth factor receptor (EGFR) inhibitor cetuximab, and radiation therapy. EXPERIMENTAL DESIGN: Patients with ra...

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Hlavní autoři: Argiris, Athanassios, Duffy, Austin G., Kummar, Shivaani, Simone, Nicole L., Arai, Yoshio, Kim, Seungwon W., Rudy, Susan. F., Kannabiran, Vishnu. R., Yang, Xinping, Jang, Minyoung, Chen, Zhong, Suksta, Nanette, Cooley-Zgela, Theresa, Ramanand, Susmita G., Ahsan, Aarif, Nyati, Mukesh. K., Wright, John J., Van Waes, Carter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368806/
https://ncbi.nlm.nih.gov/pubmed/21750205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0861
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