The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

BACKGROUND: Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic agents. Recent evidence has suggested that oligoden...

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Autori principali: Gray, Elizabeth, Ginty, Mark, Kemp, Kevin, Scolding, Neil, Wilkins, Alastair
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368767/
https://ncbi.nlm.nih.gov/pubmed/22480361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-63
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