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Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ(42) Peptide
Abnormal interactions of Cu and Zn ions with the amyloid β (Aβ) peptide are proposed to play an important role in the pathogenesis of Alzheimer’s disease (AD). Disruption of these metal–peptide interactions using chemical agents holds considerable promise as a therapeutic strategy to combat this inc...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3368506/ https://ncbi.nlm.nih.gov/pubmed/22452395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja210588m |
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