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Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ(42) Peptide

Abnormal interactions of Cu and Zn ions with the amyloid β (Aβ) peptide are proposed to play an important role in the pathogenesis of Alzheimer’s disease (AD). Disruption of these metal–peptide interactions using chemical agents holds considerable promise as a therapeutic strategy to combat this inc...

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Detalhes bibliográficos
Main Authors: Sharma, Anuj K., Pavlova, Stephanie T., Kim, Jaekwang, Finkelstein, Darren, Hawco, Nicholas J., Rath, Nigam P., Kim, Jungsu, Mirica, Liviu M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368506/
https://ncbi.nlm.nih.gov/pubmed/22452395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja210588m
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