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The outs and the ins of sphingosine-1-phosphate in immunity
The potent lipid mediator sphingosine-1-phosphate (S1P) is produced inside cells by two closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a crucial regulator of immunity. Many of the actions of S1P in innate and adaptive immunity are mediated by its binding to five...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3368251/ https://ncbi.nlm.nih.gov/pubmed/21546914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri2974 |
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