The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the Cyclin-CDK-Rb pathway

Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both diagnostic and therapeutic importance. Models of dysplasia that help elucidate the...

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Bibliographic Details
Main Authors: Cabrera, M. Carla, Díaz-Cruz, Edgar S., Kallakury, Bhaskar V. S., Pishvaian, Michael J., Grubbs, Clinton J., Muccio, Donald D., Furth, Priscilla A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368087/
https://ncbi.nlm.nih.gov/pubmed/22508966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0532-T
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