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A Two-Step Mechanism for Cell Fate Decision by Coordination of Nuclear and Mitochondrial p53 Activities

The tumor suppressor p53 has a crucial role in the DNA damage response. Here, we proposed an integrated model of the p53 network and explored how the nuclear and mitochondrial p53 pathways are coordinated to determine cell fates after [Image: see text]-irradiation in radiosensitive tissues. Using nu...

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Autors principals: Tian, Xiao-Jun, Liu, Feng, Zhang, Xiao-Peng, Li, Jun, Wang, Wei
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367989/
https://ncbi.nlm.nih.gov/pubmed/22679490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038164
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