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A Two-Step Mechanism for Cell Fate Decision by Coordination of Nuclear and Mitochondrial p53 Activities
The tumor suppressor p53 has a crucial role in the DNA damage response. Here, we proposed an integrated model of the p53 network and explored how the nuclear and mitochondrial p53 pathways are coordinated to determine cell fates after [Image: see text]-irradiation in radiosensitive tissues. Using nu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367989/ https://ncbi.nlm.nih.gov/pubmed/22679490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038164 |
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