DNA mismatch repair proficiency executing 5-fluorouracil cytotoxicity in colorectal cancer cells

BACKGROUND: 5-fluorouracil (5-FU)-based chemotherapy is the standard treatment for advanced stage colorectal cancer (CRC) patients. Several groups including ours have reported that stage II-III colorectal cancer patients whose tumors retain DNA Mismatch repair (MMR) function derive a benefit from 5-...

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Bibliographic Details
Main Authors: Iwaizumi, Moriya, Tseng-Rogenski, Stephanie, Carethers, John M
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367669/
https://ncbi.nlm.nih.gov/pubmed/21814034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.8.17169
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