A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification

The MLL-AF4 fusion gene is a hallmark genomic aberration in high-risk acute lymphoblastic leukemia in infants. Although it is well established that MLL-AF4 arises prenatally during human development, its effects on hematopoietic development in utero remain unexplored. We have created a human-specifi...

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Bibliographische Detailangaben
Hauptverfasser: Bueno, Clara, Montes, Rosa, Melen, Gustavo J, Ramos-Mejia, Verónica, Real, Pedro J, Ayllón, Verónica, Sanchez, Laura, Ligero, Gertrudis, Gutierrez-Aranda, Iván, Fernández, Agustín F, Fraga, Mario F, Moreno-Gimeno, Inmaculada, Burks, Deborah, del Carmen Plaza-Calonge, María, Rodríguez-Manzaneque, Juan C, Menendez, Pablo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367544/
https://ncbi.nlm.nih.gov/pubmed/22212479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.4
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