AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis

Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleo...

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Bibliographic Details
Main Authors: Ji, Haitao, Ding, Zhiyong, Hawke, David, Xing, Dongming, Jiang, Bing-Hua, Mills, Gordon B, Lu, Zhimin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367238/
https://ncbi.nlm.nih.gov/pubmed/22510990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.53
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