AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis

Although Niban is highly expressed in human cancer cells, the cellular functions of Niban remain largely unknown. We demonstrate here that ultraviolet irradiation induces phosphorylation of Niban at S602 by AKT, which increases the association of Niban with nucleophosmin and disassociation of nucleo...

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Autori principali: Ji, Haitao, Ding, Zhiyong, Hawke, David, Xing, Dongming, Jiang, Bing-Hua, Mills, Gordon B, Lu, Zhimin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367238/
https://ncbi.nlm.nih.gov/pubmed/22510990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.53
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